Terms to know about cell firing
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Na+ (sodium) |
The major positive ion in the fluid outside the cell: it can leak into the cell. |
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K+ (potassium) |
The major positive ion inside the cell. It can leak in and out. |
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Na+/K+ ATPase, or Na+/K+ pump |
An enzyme that uses ATP for fuel, to pump the Na+ back out of the cell and pump the K+ back into the cell |
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Cell resting potential (also called Em) |
This is the charge inside the cell when it is at rest. It is around -90 millivolts, because the cell contains negatively charged proteins. |
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Ion channels or ion gates |
Proteins in the cell membrane that let particular ions through |
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Ligand-gated Na+ channels |
These are gates for Na+, and they will open when a chemical from outside the cell binds to them (like a molecule you're smelling or tasting). Then Na+ can go into the cell. |
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Voltage-gated Na+ channels |
These are gates for Na+ that will open when the cell charge becomes more positive (for instance, when you get an electric shock). Then Na+ can go into the cell. |
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Depolarization |
This is when Na+ gates open and Na+ goes into the cell, making it become more positive. |
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Threshold potential (Et) |
As the cell gets more positive, it reaches a charge at which the voltage-gated Na+ channels will open. This is the threshold potential. It is around -50 to -70 mV. |
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Action potential (Ea) |
When Na+ has flooded into the cell, the cell becomes as positive as it can. This is its action potential. |
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Voltage-gated K+ channels |
These K+ channels open when the cell reaches action potential, and let the K+ flow out of the cell. |
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Repolarization |
This is when the K+ leaves the cell, making the cell become negative again. |
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Refractory period |
This is a short period after the cell repolarizes, when it can't fire again until it has 'reset' itself. |
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Hyperpolarized |
A cell whose resting potential is too negative - that is, instead of being -90mV, it might be -120 mV. This cell will not fire as easily as usual. |
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Hypopolarized |
A cell whose resting potential is not negative enough - instead of being -90 mV, it might be -70 mV. This cell will fire easily. |
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Sensitivity |
How easily a cell fires. This depends on how hard it is to raise the cell's charge from its resting potential to the threshold potential. |
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K+ effect on resting potential |
Increasing the amount of K+ outside the cell will make the resting potential more positive and hypopolarize the cell. Decreasing the amount of K+ outside the cell will make the resting potential more negative and hyperpolarize the cell. |
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Extracellular Ca2+ |
When Ca2+ is outside the cell, it can block the Na+ channels. This makes it harder for the cell to fire. |
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